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KMID : 0359320150550010021
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Korean Journal of Veterinary Research
2015 Volume.55 No. 1 p.21 ~ p.30
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Protective effect of Hizikia fusiforme on radiation-induced damage in splenocytes
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Kim A-Reum
Bing So-Jin
Cho Jin-Hee
Ahn Gin-Nae
Lee Ji-Hyeok
Jeon You-Jin
Lee Byung-Gul
Jee Young-Heun
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Abstract
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The immune system is specifically sensitive to oxidative stress induced by ionizing radiation because of its rapid proliferative activity. For this reason, an instructive immune system is one of the best ways to minimize side effects, such immunodeficiency, of gamma radiation. Over the past few decades, several natural plants with antioxidant and immunomodulatory properties have been identified as adjuncts for nontoxic and successful radiotherapy. Hizikia fusiforme extract (HFE) containing plentiful dietary fiber and fucoidan is known for its instructive antioxidant capacity, immunomodulation abilities, and immune activation. In this study, we determined whether HFE protects radiosensitive immune cells from gamma radiation-induced damage. C57BL/6 mice were irradiated with gamma-ray. The effect of HFE on the ionizing radiation damage of immune cells was then evaluated with an MTT assay, 3Hthymidine incorporation assay, and PI staining. We found that HFE stimulated the proliferation of gamma-ray irradiated immune cells without cytotoxic effects. We also observed that HFE not only decreased DNA damage but also reduced gamma radiation-induced apoptosis of the immune cells. Our results suggest that HFE can protect immune cells from gamma-ray damage and may serve as an effective, non-toxic radioprotective agent.
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KEYWORD
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gamma-ray, Hizikia fusiforme, immune cell, natural functional product, oxidative stress
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